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Effects of a quasi-experimental study of using flipped classroom approach to teach evidence-based medicine to medical technology students



Flipped classroom is known to improve learning efficiency and to develop one’s ability to apply high-level knowledge. To investigate the effect of flipped classroom approach on teaching evidence-based medicine to medical technology students, we conducted a tailor-made six flipped classroom based EBM courses for medical technology students.


This study adopted a qusai-experimental design with 62 medical technology interns as the research object. Students in the experimental group attended the flipped classroom course, while students in the control group attended the traditional course. The learning outcomes were evaluated by Fresno test in both groups. Furthermore, to understand student’s perceptions on the flipped classroom approach, students in the experimental group were required to fill in a satisfaction survey and answer some open-ended questions.


The Fresno test scores of the experimental group were significantly higher than that of the control group. From the results of the satisfaction survey, we know that students were satisfied with this course format. Students claimed that the flipped classroom approach could improve their learning efficiency and the interactions with teacher could help them to think more deeply.


To conclude, most students showed positive attitudes and views on flipped classroom strategy. Moreover, students’ questions were solved more effectively during class resulting in an improvement of effectiveness of evidence-based medicine trainings.

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Evidence-based medicine (EBM) is a combined knowledge of clinical problems, patient’s values, research evidences and clinical experiences [1]. In 2003, the Institute of Medicine (IOM) has published an article, health professions education: A bridge to Quality, in which 5 core competencies in reconstruction of medical professional education are presented. The 5 core competencies include patient-centered care, medical team operation, EBM training, quality promotion and information system application [2]. As EBM supports the acquisition of evidence in an accurate, clear and knowledgeable way, the implementation of EBM in clinical practice will provide a guideline for selection of the most appropriate patient care based on the best available evidence [3, 4]. Solving clinical problems by applying EBM techniques is the main emphasis in Western medical practice, therefore, all medical staffs in a patient-centered cross-disciplinary medical care team should acquire EBM skill [5].

Studies suggested that it is necessary to provide EBM trainings to medical technologists allowing them to develop problem-solving skills and to integrate knowledge for other medical staffs as inspection consultation or interpretative comments [6]. Currently, several hospitals in Taiwan, the Taiwan Evidence-Based Medicine Association, and the Taiwan Society of Laboratory Medicine are offering EBM courses to medical technologists. The main difficulties in teaching EBM to medical technologists are that most of the courses are traditional lecture-style teaching and there is a limited amount of literature focused on laboratory diagnostics in the medical databases. However, a systematic review of EBM teaching suggests that using a single teaching method can strengthen only theoretical knowledge [7]. When EBM is combined with clinical case practicing as a blended-learning model, a considerable improvement in knowledge, skill acquaintance, and learning attitude is observed [8].

With the rapid development of the Internet, the learning style of learners has been changed. Moreover, teaching is no longer limited by time and location. Thus, teachers are able to utilize varies teaching modes and appropriate methods. For a long period of time, teacher is the center of the teaching style of medical education, in which giving a lecture to a group of learner is the main way of teaching [9]. The teaching content mainly consists of knowledge learning and concept understating. Learners have to attend lectures and study in class. And a large number of repeated exercises and tests are required to enhance learners’ competence of understanding [10]. In this teaching model, there is often a lack of interactions between teachers and learners. Learner often does not actively think leading to poor development of his or her cognitive ability [11].

Flipped classroom, an emerging wave in teaching, is considered as a variant of blended-learning model [12]. Instead of providing traditional in-class lectures, the concept of flipped classroom teaching is to teach the basic concept online and to trigger discussion, problem solving and extended thinking during class [13]. As student-centered learning is the core of flipped classroom teaching, the main task of the teacher is to discuss concepts and constructs with students, but not to give lectures. The success of the flipped classroom is mainly due to the increasing convenience of the Internet network that enables motivated students to learn independently through an online teaching platform [14]. Students who learn from the flipped classroom model are more focused during learning. Both their critical thinking skills and their learning attitude are improved [15]. Furthermore, students who are responsible for their own learning activity become active learners [16, 17]. Through peer feedback and learning by doing, knowledge is translated into experience [18].

Although the flipped classroom teaching method has received a positive reaction in most systematic review and aroused a great interest in medical community [15, 19,20,21], the application of flipped classroom model to EBM teaching or medical technologist training has been limited. The current EBM teaching focuses on solving treatment problems, which does not meet the training requirements of medical technologists. In this study, aiming to emphasize on medical technology educations, we designed a flipped classroom EBM (FC-EBM) course tailor-made for medical technology students. The learning efficiency of the FC-EBM course and the traditional classroom EBM (TC-EBM) course was evaluated with Fresno test. Furthermore, we tried to understand student’s opinions and attitudes towards the FC-EBM course through analyzing the satisfaction survey completed by students who had attended the FC-EBM course.



Quasi-experimental designs [22] were applied to understand whether the implementation of the flipped classroom approaches affects the learning efficiency of EBM. This study was approved by the ethical committee of the Kaohsiung Chang Gung Memorial Hospital, Taiwan (IRB no. 201600978B0 and no.201700615B0).


A total of 62 medical technology students from Kaohsiung Chang Gung Memorial Hospital were enrolled for this study. The control group consisted of 24 students who attended the TC-EBM. The experimental group consisted of 38 students who attended the FC-EBM. All participants had no previous experience in EBM learning. The characteristics of each group are shown in Table 1.

Table 1 Characteristics of the Control and Experimental Group


The class format of the experimental and the control group is illustrated in Table 2. Both groups of students were conducted once a week for 6 weeks and performed the Fresno test 1 week after the end of the course. Since all participants had no experience on attending EBM and flipped classroom course, the design and the procedure of the course were explained before class. Course preparation consisted of the following tasks (Fig. 1): (1) Establishing a learning platform, (2) Course description, (3) Counseling mechanism and (4) Gather information. Activities during class incorporated various components: (1) Student grouping and (2) Curriculum planning.

Table 2 Class format for control and experimental group
Fig. 1
figure 1

Flowchart of flipped classroom lessons

In order to facilitate the reading of students who participated in the flipped classroom course, the contents of the traditional teaching course were streamlined into online self-study eBook (Fig. 2). The case study “reducing the hemolysis rate”, which was discussed in the traditional course, was selected as the main focus of the FC-EBM course [23]. Seven eBook learning units were produced as follows: (1) introduction to EBM, (2) asking questions, (3) finding evidence, (4) type of experiment, (5) reviewing literature, (6) clinical effects and (7) clinical use. The main focus of each eBook unit was summarized and the unit reading time was less than 15 min for student to self-learning at home. Three clinical cases were discussed during class lasted for about 30 min per session.

Fig. 2
figure 2

Using SimMAGIC eBook software to create interactive multimedia eBook units of evidence-based medicine

Each TC-EBM course lasted for at least 1 h per session. The subjects of the traditional teaching courses were (1) basic concepts of EBM, (2) questioning and finding evidence, (3) commonly used research design, (4) reviewing the validity, importance and practice of evaluating literatures and (5) discussing four clinical questions. Problem set was arranged for students who attended the TC-EBM course to practice after class. Student could discuss with teacher in person or through the Line App before class and the teacher would give the answer before next class.


This study adapted Fresno test to evaluate a learner’s knowledge in EBM. The test is a standardized and objective tool to measure one’s competence on the application of EBM [24]. It consists of four domains that include the following: asking clinical question (PICO question), searching strategy, developing critical appraisal skill and applying to clinic. The duration of the test was 30 min. To provide a detail description of the opinions and attitude of implementing flipped classroom to EBM trainings, self-made 14 questions satisfaction survey (Likert 5-point scale) and open-ended questions were used in experimental group.

Statistical analysis

The demographic data for the control group and the experimental group were examined via chi-square and two-tailed t-tests. Continuous variables were presented as mean ± standard deviation and were analyzed with Mann-Whitney U test. Probability value below 0.05 was considered as statistically significant. All statistical analyses were performed using GraphPad Prism 5.01 (La Jolla, CA).


Participant characteristics

The age, gender and education level were similar in both the experimental and control group (Table 1). Most of the participants are college students and most of them are female. Table 2 shows the course timing and curriculum information of the different teaching models. Both groups used the Line app as the information technology. The teaching materials of the flipped classroom course were stored on the digital learning platform, while the teaching materials of the traditional course were supplied in paper format. In terms of course structure and format, the teacher, the assessors, the number of lecture and the study cases were identical in both groups. Only the number of student in each discussion group was different in each group.

Quantitative findings

Students who attended the flipped classroom-based course (Table 3) had completed all tests and filled in the satisfaction surveys. FC-EBM trained students had a higher Fresno test score than TC-EBM trained students (64.28 ± 12.27 vs 31.46 ± 11.34, p <  0.001) (Fig. 3). FC-EBM trained students also had higher average scores on each component of the EBM applications compared to TC-EBM students (Table 4). Of note, the clinical application aspect was again significantly improved (FC-EBM vs TC-EBM: 20.45 ± 6.37 vs 5.54 ± 5.65 vs, p <  0.001).

Table 3 Outline of the flipped classroom courses
Fig. 3
figure 3

Student’s competence on the application of EBM was scored using Fresno test

Table 4 Results of Fresno tests

Students who attended the FC-EBM course were satisfied on every aspect listed in the satisfaction survey and scored more than 4 on each item. The satisfaction scores for the interactive eBook, case discussion and flipped classroom-based course were 4.40 ± 0.55, 4.46 ± 0.55 and 4.35 ± 0.62, respectively (Table 5). Among the 14 questions in the satisfaction surveys, the top three most satisfied features were “Teachers provided suitable answers to student’s questions” (4.58 ± 0.50), “Teachers encouraged and provided opportunities for students to ask questions” (4.56 ± 0.53), and “ The content of this course fulfilled the teaching aims” (4.53 ± 0.53).

Table 5 Results of the satisfaction survey

Analysis of supplementary open-ended questions

In order to gain a deeper understanding of students’ perceptions and attitudes on flipped classroom, we collected and analyzed the students’ feedback by open-ended questions in the satisfaction survey. Analysis was based on two categories: the effectiveness of such models for learning and the adjustment of classroom environment. Factors that lead to satisfaction include interactive eBooks and in-class case discussions. For example, they mentioned that self-studying the eBook before the start of the course was helpful. The following statements are comments from the students’ feedback (student’s statements are kept unchanged in sentences in italics):

The contents of the eBook are well organized.

Each eBook learning unit is completed in 5-10 minutes. It’s pretty easy for me to study.

The eBook included questions related to real life issue which were easy to follow.

In addition, students mentioned that compared to the monotonous theoretical teaching in traditional teaching, flipped classroom course allowed them to be well prepared before class by self-studying the eBook. In addition, through the active discussion of clinical cases later on class, students had a chance to put the knowledge into practice enhancing their learning effectiveness. In addition, active discussion of clinical cases during class enable students to put their knowledge into practice resulting in improvement of learning effectiveness. Some feedbacks from students are:

The teacher discussed each question with us. This helped us to clarify some of the content and to comprehend the content better.

Through the learning process of the flipped classroom course, questions were solved in a more organized way. Therefore, it was easier for me to solve each question.

I gained better understanding of the eBook during class when teacher was discussing with us. When I first read the eBook, I didn’t know how to put into practice. After discussing with the teacher, I was able to relate back to the contents in the eBook.

Nevertheless, few students found self-study difficult:

As there were too much attractions at home or in the dormitory, I found it difficult to focus on studying the eBook. The effect of self-study was moderate and I had to read it for more than 2 times to understand the content.

EBook do not have to include narrations which may sometimes affect reading. For better reading, only supplementary information could be explained by audio records.

Some contents of the eBook are difficult to understand. To have better understanding, I have to search for references.


In this study, we designed a FC-EBM course focusing on diagnosis problems. Students who participated in the FC-EBM course had significantly higher scores in the Fresno test than the control group. In terms of EBM knowledge, our results show that the teaching strategies and the course design of EBM are in line with the training of medical technologists and are effective for acquisition of knowledge. Flipped classroom strategy is a student-centered active learning technique allowing students to focus on high-level cognitive learning [25]. The implementation of flipped classroom strategy in teaching EBM allows students to develop critical thinking, analyze medical evidences rationally and practically apply their knowledge to clinical care.

These findings were similar to other flipped classroom courses reported by others [26, 27]. Through the theory of Bransford’s science of learning which focuses on the perspective of both teacher and student, we can understand why flipped classroom strategy is effective in learning EBM [28]. This is because flipped classroom strategy engaged students (1) to know new concept and information in advance, (2) to have factual knowledge for concepts understanding, references searching and knowledge application, (3) to apply metacognitive strategies for self-learning through self-monitoring.

Although the classroom time of flipped classroom course is shorter than the traditional teaching, the Fresno test scores of the flipped classroom course are significantly higher than that of the traditional course. The possible reason is that the main focus of flipped classroom strategy is to transmit information, with the shortening of teaching time, the accuracy of learning is increased and the cognitive load level is reduced [29, 30]. In addition, as students know that teacher is monitoring their learning status through the digital platforms, students have the peer pressure that eventually turn to active leaning. This make them more engaged in learning as well. Moreover, flipped classroom is considered as a useful tool for teaching high-risk students as they have longer time to interact with teacher and obtain more helps from powerful peers.

Our quantitative results are further supported by our supplementary open-ended questions feedback that provide insights of student’s perceptions on the flipped classroom strategy. In short, students like the flipped classroom course as both the self-study eBook and the study cases can be explored in depth through frequent teacher-student interactions and peer interactions. In this study, lively cases were discussed allowing students to build knowledge from their past experience and interactions with their group mates. This also helps to develop one’s ability in problem integration, critical thinking and social networking [31].

The results of this study let us believe that medical technology students favored FC-EBM model than TC-EBM model. From the perspective of generations, the possible reason is that all the participants are medical technology interns who belong to the generation Y. In this generation, due to the rapid development of information technology, their learning sources are no longer limited to books. They often conduct learning activities through information and communication technologies such as smart phones or tablets. Thus, our flipped classroom strategy not only changes the teaching and learning activities and the habits of teacher and students, but also meets the learning needs of generation Y.

From the results of the satisfaction survey, it is shows that students are satisfied with acquiring the skill of EBM but they may have low willingness to apply EBM in solving clinical problems. The probable cause is that participants in this study were interns who did not have sufficient clinical experiences. Nieman and colleagues also reported that interns may not fully understand the important of solving clinical problems with EBM methodology [32]. In the future, to strengthen the students’ ability of solving clinical problems, clinical laboratory counseling or questions in patient care from the multidisciplinary medical team should be discussed after the EBM course. These clinical problems are actually the foregrounded questions in EBM learning. Using the skills of EBM, students can be asked to identify relevant literature, discuss issues face-to-face with physicians, and assist physicians and cross-disciplinary teams in solving patient problems.

There were some limitations in this study. First, the experimental setting was not ideal as participants could not be randomly assigned in an educational environment. Second, the number of participants in this quasi-experiment was low. Future use of this teaching model in a larger group is needed to determine whether these results are generally consistent. Third, as teachers and students were participating a research, there might be Pygmalion effect in which student’s performance is affected by teacher’s expectations [33]. Lastly, our course contained only 6 classes in a total of 3 h of training time that was not enough to predict the long-term training performance. Thus, more studies will be needed for long-term tracking of the learning effect and to determine whether the beneficial outcomes of FC-EBM course is sustainable.

In this study, in order to support and strengthen the training of medical technologists, a flipped classroom based EBM course was developed exclusively for medical technology interns. From our analyses, it is known that the use of flipped classroom strategy to train medical technology interns is effective. This not only enhances the learning experience of students, but also introduces many positive effects.


In this study, we created a EBM courses with 6 sessions implements with a flipped classroom model. According to the analytic results, flipped classroom model can improve the effectiveness of EBM learning of medical technology interns. Most students are satisfied with this teaching method, indicating that this teaching method has been well accepted by students. Yet the duration of the course was short and the number of participant was low. Thus, a long-term study with a larger group of student will be needed to verify our current findings.

Availability of data and materials

Not applicable.



Evidence-based medicine


The flipped classroom in teaching evidence-based medicine


Patient, intervention, comparison, outcome


The traditional classroom in teaching evidence-based medicine


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We also thank Dr. Boyd Davis for her instructive advice and useful suggestions on this research.


This study was financially supported by the Kaohsiung Chang Gung Memorial Hospital, Taiwan (Grant no. CDRPG8G0011) and Ministry of Science and Technology of Taiwan (Grant no. 106–2511-S-182-010 to C.H.C).

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Authors and Affiliations



HLH and CHC are the chief designers of this study. CPC and MMT are responsible for reviewing EBM course and grade the Fresno test. SL and HLY are responsible for data analysis and manuscript preparation. All authors have approved the revisions of the manuscript and agreed to the publication of the final manuscript.

Authors’ information

Hsien-Li Huang, MT, MS, is a member of the Center for Faculty Development at Kaohsiung Chang Gung Memorial Hospital, Taiwan. He is currently a PhD student in the Graduate Institute of Adult Education at National Kaohsiung Normal University, Taiwan.

Chia-Pei Chou, MD, is a medical doctor with fellowship training in Family Medicine. She is a member of the Center for Evidence-Based Medicine at Kaohsiung Chang Gung Memorial Hospital, Taiwan.

Steve Leu PhD, received his PhD degree from Chang Gung University, Taiwan. He is an associate professor at the Institute for Translational Research in Biomedicine at Kaohsiung Chang Gung Memorial Hospital, Taiwan.

Huey-Ling You, MT, PhD, is a chief medical technologist at the department of laboratory medicine at Kaohsiung Chang Gung Memorial Hospital, Taiwan. She is an associate professor at the Department of Medical Laboratory Sciences and Biotechnology at Fooyin University and a member of the Center for Faculty Development at Kaohsiung Chang Gung Memorial Hospital, Taiwan.

Mao-Meng Tiao, MD, BS, is a medical doctor with fellowship training in Pediatrics. He received his BS degree in Master of Clinical Education from Flinders University, Australia. He is a professor of Medicine at Chang Gung University and the Chief of the Center for Evidence-Based Medicine at Kaohsiung Chang Gung Memorial Hospital, Taiwan.

Chih-Hung Chen, MD, is a medical doctor with fellowship training in Internal Medicine and Gastrointestinal Medicine; currently a PhD student in the Graduate Institute of Adult Education at National Kaohsiung Normal University, Taiwan. He is an assistant professor of Medicine at Chang Gung University and a member of the Center for Faculty Development at Kaohsiung Chang Gung Memorial Hospital, Taiwan.

Corresponding author

Correspondence to Chih-Hung Chen.

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This study was approved by the Committee on Ethics of the Kaohsiung Chang Gung Memorial Hospital, Taiwan (IRB no.201600978B0 and no.201700615B0). Written informed consent was obtained from all participants after all aspects of this study were explained.

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Huang, HL., Chou, CP., Leu, S. et al. Effects of a quasi-experimental study of using flipped classroom approach to teach evidence-based medicine to medical technology students. BMC Med Educ 20, 31 (2020).

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