Table 2 Confidence of hospital pharmacists to identify antimicrobial stewardship interventions upon review of antimicrobial prescribing
Antimicrobial stewardship intervention | Confidence % (n) | ≤2 years of registration % (n) | ≥3 years of registration % (n) | P valuea |
|---|---|---|---|---|
Dose optimization based on patient-specific factors | 75.0 (303/404) | 67.6 (48/71) | 76.6 (255/333) | 0.11 |
Therapeutic drug monitoring | 68.5 (278/406) | 53.5 (38/71) | 71.6 (240/335) | 0.003 |
Antibiotic allergy assessment | 67.1 (273/407) | 59.2 (42/71) | 68.8 (231/336) | 0.19 |
Discontinuation, recommended duration reached | 65.0 (264/406) | 51.4 (36/70) | 67.9 (228/336) | 0.009 |
Streamlining according to guidelines | 63.2 (258/408) | 56.3 (40/71) | 64.7 (218/337) | 0.18 |
Intravenous-to-oral antimicrobial switch | 63.0 (255/405) | 38.0 (27/71) | 68.3 (228/334) | < 0.001 |
De-escalating based on microbiology results | 61.5 (251/408) | 53.5 (38/71) | 63.2 (213/337) | 0.13 |
Inappropriate therapeutic duplication | 55.2 (224/406) | 39.4 (27/71) | 58.8 (197/335) | 0.001 |
Unlikely infection, antibiotics unnecessary | 54.9 (224/408) | 40.8 (29/71) | 57.9 (195/337) | 0.009 |
Inappropriate lack of spectra of activity | 50.2 (204/406) | 33.8 (24/71) | 53.7 (180/335) | 0.002 |
Bug-drug mismatch | 46.8 (190/406) | 32.4 (23/71) | 49.9 (167/335) | 0.007 |
Dose optimization based on infection-specific factors | 44.3 (178/402) | 28.2 (20/71) | 47.7 (158/331) | 0.003 |