Table 2 Summary of Course Objectives

1

• Describe the structure and function of DNA, chromosomes and genes.

• Describe patterns of inheritance, including Mendelian (e.g., autosomal dominant, autosomal recessive, and sex-linked transmission of genetic traits) and non-Mendelian (e.g., genetic heterogeneity and variable expression, genetic instability, mitochondrial and multifactorial inheritance); evaluate the scope, significance, and implications of the Human Genome Project and Genetic Information Non-Discrimination Act.

• Describe the major mechanisms underlying genetic variation, including epigenetics, the techniques used to identify and quantify variation, and the molecular and clinical consequences of variation.

2

• Explain and discuss ethical, legal, and social issues in genomics.

• Develop familiarity with the fundamental genomics competencies for registered nurses and advanced practice nurses; obtain and diagram a 3-generation family history and pedigree.

• Explain and discuss issues related to diversity relevant to genomics.

• Identify applications of genomics in clinical laboratories; discuss issues related to direct to consumer testing.

• Analyze the differences and overlap between genomics in research and clinical practice.

• Understand the Precision Medicine Initiative and implications for citizens, patients, and providers.

3

• Identify clinical applications of genomics across the lifespan.

• Gain familiarity with current clinical implications of genomics for common diseases (e.g., cancer, neurological disease).

• Articulate how to pursue a Certified Genetic Nurse credential.

• Evaluate the research and resources relevant to providers and patients in your clinical specialty area.