Knowledge of physicians regarding the management of Type two Diabetes in a primary care setting: the impact of online continuous medical education

Background To explore the impact of an online continuing medical education (CME) program on physicians’ knowledge about the management of type two diabetes. Methods An online CME program was designed and uploaded in the CME platform, Department of Education, Ministry of health, Iran. A 28-item questionnaire was used for the assessment. In the beginning, a case scenario was introduced. Then, participants were asked to follow and answer to a pretest assessment. Details of the educational content were provided afterward. Finally, the participants took part in the same post-test exam 4 weeks later. The Wilcoxon matched-pairs signed-ranks test was used to compare the measurements. In addition, the Mann-Whitney test was applied to compare knowledge indices between the general practitioners (GPs) and internists. Results Five hundred twenty-six primary care physicians participated in this study. There was a significant positive effect regarding diagnosis confirmation (10.3% difference, P = 0.0001). Moreover, a smaller effect was observed in relation to the importance of glycosylated hemoglobin (HbA1c) at diagnosis (5.2% difference, P = 0.0006). The effect was positive in relation to the self-reported HbA1c testing frequency: more than 90% of the participants answered correctly in the post-test exam (7.6% difference, P = 0.0001). Considering improved knowledge in the treatment of diabetes, there was a very significant difference in response to questions targeting advice on a healthy diet, and physical activity; 27.7% (P = 0.000), and 18.7% (P = 0.000), respectively. In addition, the program had a positive impact on various aspects of treatment with oral glucose-lowering drugs (OGLDs). Moreover, the intervention difference was 25, and 34.4% for the questions targeting the appropriate type of insulin, and insulin initiation regimen after OGLD failure. Subgroup analyses revealed that the intervention increased the rate of correct responses among the GPs in various domains of knowledge in diagnosis and treatment. The initial differences between the GPs and internists no longer remained significant after the intervention. Conclusion Knowledge of Iranian primary health care professionals in diabetes management has significant shortcomings. This is concerning because they are at the front line of patient care. We demonstrate the effectiveness of online CME on improving GPs knowledge in the management of type 2 diabetes.


Background
Diabetes, one of the most common endocrine disorders, is a leading cause of death worldwide [1]. The prevalence of diabetes is estimated to increase from 425 to 629 million by 2045 [2]. More than 9% of diabetic patients are from the Middle East and North Africa [3]. In Iran, 11.5% of the adult population has diabetes. Approximately 50% of deaths related to diabetes occur in patients under the age of 60 years [4]. Hence, timely diagnosis and good control of diabetes may prevent or delay the development of longterm adverse outcomes [5].
Primary healthcare professionals are frontline care providers in the management of diabetes and its complications [6][7][8]. The complexity and chronicity of diabetes are challenging for healthcare professionals; thus improving and updating physician ' s knowledge and performance through education is essential [9]. The main objectives of diabetes management are to control risk factors, achieve desired glycemic goals, and prevent diabetes-related complications in order to improve patients' quality of life [9]. In this context, continuing medical education (CME) is defined as any activity applied to maintain, develop, and improve the knowledge, skills, and professional performance of physicians [10,11].
The disadvantages of traditional CME include being teacher-oriented, having an in-person-based approach, high cost, low educational quality, time constraints, widespread geographical distribution, and time away from work [12]. The emerging concept of CME concurrent with the increasing growth of information technology and electronic devices have led specialists to consider electronic education as a substitute or supplementary method in the field of education in recent years [13,14].
Online CME as a web-based technology has been validated as an effective modality to make changes in the knowledge and behavior of physicians and to improve their confidence [15][16][17]. It is searchable, accessible, and on-demand. It is cost-effective and a strong source of CME for a large audience in their busy lives [18]. Today, the use of online CME is growing [19]. Numerous studies have found online CME to be a useful tool in palliative care training for healthcare professionals [20,21]. Recently, a systematic review reported the positive impacts of online CME regarding the knowledge and satisfaction of general practitioners (GPs); however, the best delivery method is yet to be determined [22].
Several investigations have evaluated the beneficial effects of online CME programs on the medical knowledge, practice, and behavior of healthcare providers [22,23]. In recent years, online CME activities have focused on serious illnesses such as diabetes in different groups of healthcare providers including GPs [24], nurses [25], and internal medicine physicians [26]. Most studies have indicated that online CME interventions improve participants' diabetes knowledge and management skills in the areas of nutrition [27], monitoring metabolic markers [26], and managing dyslipidemia [28], as well as the clinical knowledge and confidence of physicians in using new medications, including GLP1 receptor agonists [29]. However, the influence of online CME programs based on American Diabetes Association (ADA)/ the European Association for the Study of Diabetes (EASD) guidelines [30] on the knowledge of healthcare providers, especially GPs and internists, is not clearly understood Previously, we showed that 40% of Iranian primary healthcare professionals took part in CME-accredited programs in diabetes, the majority being from large cities [31]. Hence, online CME could potentially provide an opportunity for equality in education. Currently, certified academic centers are responsible for delivering CME programs in Iran. The impact of the programs should be evaluated in order to improve their content and the methods of delivery. Hence, the aim of this study was to explore the impact of an online CME program on physicians' knowledge in the diagnosis and treatment of type 2 diabetes in the primary care setting.

Methods
This cross-sectional study was conducted on physicians involved in the management of diabetes in a primary healthcare setting. The Institute of Endocrinology and Metabolism is one of the certified academic centers eligible to run online CME programs in Iran. All online CME programs are uploaded in a platform provided by the Deputy of Education, Ministry of Health, available at http://ircmelms.ir. Healthcare professionals from all over the country have access to this platform and can participate in the programs according to their educational needs. The current online CME program was uploaded on the platform and active from November 21, 2017 until November 22, 2018.
The sample size was calculated to be 531, using the formula n ¼ zα 2 2 σ 2 d 2 , a confidence level of 0.05, absolute error value of d = 1.05, and standard error for knowledge of 12.35 [32]. Excluding 5 participants who did not answer to the post test questionnaire, data from 526 participants who completed both pre-test and post-test questionnaires were analyzed.
The program was designed in four steps. Initially, the participants were provided with the instructions and the main objectives. In the second step, they were asked to follow and answer to the pre-test questions. Then, the details of the educational content, including a video presentation, PowerPoint slides, and useful links to the ADA/EASD guidelines [30] were provided to them. The video presentation contained the most relevant content and a step-wise approach to the diagnosis and treatment of type 2 diabetes based on the latest ADA/EASD guideline. The presenting speaker was an endocrinologist with good expertise in diabetes. The PowerPoint slide presentation included details of the latest evidence in the management of diabetes. Finally, the participants were given an opportunity to respond to the post-test exam 4weeks later. They were not allowed access to the pre-test or content material at the time of the final assessment. The process steps are illustrated in Fig. 1.
A 28-item questionnaire consisting of three sections was used to assess the knowledge of the participants. The first section included questions on demographic and professional characteristics of the participants. The second section consisted of six multiple choice questions related to diagnosis (Q7, Q8, and Q9) and glycemic control (Q20, Q21, and Q22). The third section focused on the treatment of diabetes and consisted of 16 multiple choice questions related to lifestyle modification (Q10, Q11, Q12), use of oral glucose-lowering drugs (OGLDs) (Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q23), and insulin therapy (Q24, Q25, Q26, Q27, Q28). The following case scenario was presented at the beginning: "A 42-year-old man is referred to you because of a high blood sugar level detected during a screening program. He denies any symptoms related to hyperglycemia. His father had type 2 diabetes and died at age 68. There is no history of any medical problem in the past. Drug history is negative.
In physical examination, height is 170 cm, body weight is 90 kg, and BMI=30 kg/m2. Fasting plasma sugar is 212 mg/dl.
What would be your next step to confirm the diagnosis of diabetes in this patient?" To assess the questionnaire's reliability, a pilot study was performed on 100 participants. Cronbach's alpha was equal to 87%, reflecting a good level of reliability. In order to evaluate the validity of the questionnaire, six endocrinologists evaluated the questions for necessity, relevance, clarity, and simplicity. Then, the content validity index (CVI) and content validity ratio (CVR) were calculated. The overall CVI, relevance CVI, clarity CVI, and simplicity CVI were 0.812, 0.861, 0.906, and 0.824, respectively. The critical point of 0.75 was selected for the CVR [33]. All individual questions obtained CVRs ranging between 0.783 and 1.

Statistical analysis
All data was collected in an Excel file, and STATA version 10 was used for analysis of the data. Continuous variables were reported as mean (SD) and discrete ones as numbers (proportions). The equality of matched-pair (before/after) observations was assessed using the Wilcoxon matched-pairs signed-ranks test. The Mann-Whitney test was used to compare the knowledge indices regarding diagnosis and treatment scores between GPs and internists. The Pearson chi-squared and Fisher tests were used to compare GPs and internists, in either the before or after measurement times.

Ethical approval
Ethical approval was received from the Iran University of Medical Sciences ethics committee.

Results
Overall, 526 participants completed both the pre-test and post-test assessments. Table 1 shows the characteristics of the study participants. Fifty-one percent of the physicians had previously taken part in accredited CME activities; 57% were working in a large city, and 62% were employed in public healthcare services.  Table 2 indicates the effect of the intervention on the knowledge of the participants regarding diagnostic approach and glycemic control. There was a significant positive effect regarding Q7 (diagnosis confirmation, 10.3% difference, p = 0.000). A smaller but significant effect was observed in relation to the importance of glycosylated hemoglobin (HbA1c) at diagnosis (Q8, p = 0.0006). However, there was no significant difference in regard to the importance of renal and thyroid function assessment or the lipid profile measurement (Q9). The participants' knowledge of glycemic control was explored. More than 80% of the participants answered correctly to the question targeting the goal of HbA1c after treatment initiation (Q21). The effect of CME was considerable in relation to the HbA1c testing frequency; more than 90% of the participants answered correctly in the post-test. The intervention had a negative impact on the most appropriate test for assessing glycemic control ( Table 2).
The effect of the intervention on knowledge of physicians in relation to the treatment of diabetes is shown in Table 3. More than 90% of the participants recommended lifestyle modification from the onset of diabetes. There was a very significant difference in responses to questions Q11 and Q12 which targeted lifestyle change recommendations (27.7% (p = 0.000) and 18.7% (p = 0.000) intervention differences, respectively). With regard to therapy with OGLDs, there was a significant difference between the pre-and post-intervention responses to Q13 ("Do you recommend medical treatment concurrently with changes in lifestyle modification for diabetes?"), Q15 ("Do you recommend combination therapy at diagnosis for patients with relatively high HbA1c levels?"), and Q16 ("At what HbA1c value should we combine antihyperglycemic drugs?). Moreover, the effect of the intervention on starting metformin as the first OGLD (Q17, intervention difference: 16.6%, p = 0.000), the optimal dose of sulfonylurea (Q19, intervention difference: 24.4%, p = 0.000), and the highest effective dose for metformin (Q23) were significant. Conversely, there was no difference in responses to Q14, which targeted the initiation of OGLDs concurrent with lifestyle recommendations, or Q18, which asked about metformin dose at initiation. Considering insulin therapy, there was a significant difference between preintervention and post-intervention responses to questions 24 to 28 regarding insulin initiation, type of insulin, and dose titration. The intervention differences were 25 and 34.4% for questions asking the appropriate type of insulin and insulin initiation regimen after OGLD failure, respectively ( Table 3).
The means of knowledge indices in diagnosis and treatment scores before and after the educational intervention are presented in Table 4. There was a significant difference in the scores after the intervention (p-value for both = 0.0001). The impact of the intervention was more pronounced on the treatment of participants. Table 5 indicates the difference in knowledge of general physicians and internists before and after the  intervention. Regarding the diagnostic approach, a significantly higher proportion of internists gave the correct response to Q8 before and after the intervention (p = 0.025). However, there were no significant differences between the two groups in relation to the importance of diagnosis confirmation or the importance of renal/thyroid function assessment and lipid profile measurement. With regard to knowledge on glycemic control, a significantly higher proportion of internists gave the correct response to the question about HbA1c testing frequency before the intervention (p = 0.036). The difference was no longer significant after the intervention. Furthermore, no difference was observed between the groups in relation to the questions targeting the goal of HbA1c or the    (Table 5). Next, the effects of the online CME program on the treatment of GPs and internists were compared ( Table 6). A significantly higher proportion of internists gave the correct response to Q12 targeting lifestyle modification before the intervention (p = 0.043). However, the impact of the intervention on GPs was substantial. Hence, there was no significant difference between the two groups in their responses to this question after the intervention. Table 6 summarizes the changes effected by the educational intervention in the knowledge of diabetes treatment among the participants. With respect to OGLD therapy, a significantly higher proportion of internists gave the correct response to Q13 ("Recommending medical treatment concurrently with changes in lifestyle modification for diabetes") before the intervention (p = 0.043). However, there was about 18% increase in the rate of correct responses to this question among GPs. Therefore, the difference disappeared after the intervention. There was also a significant difference between the groups in response to Q15 after the intervention (p = 0.02). This question targeted the importance of combination therapy at diagnosis in patients with high HbA1c levels. There was 40% increase in the rate of correct responses among internists after the intervention. A significantly higher proportion of internists, compared to GPs, gave the correct answer to Q24 (type of insulin at initiation) before the intervention (p = 0.003); however, the intervention increased the rate of correct responses among GPs by 26%. Therefore, the difference was no longer significant after the intervention. Moreover, 35% of GPs and internists gave the correct response to Q25 ("basal insulin therapy at insulin initiation") after the intervention. Nevertheless, the rate of correct response was greater among the internists: 70.6% vs. 53.2% (Table 6).

Discussion
Improvement in the quality of diabetes care is a major challenge for healthcare systems all over the world [34].
In this context, the role of primary health care providers can not be overemphasized. Care for chronic conditions such as diabetes mellitus needs patient engagement and empowerment as well as improvement in the knowledge and skills of general physicians and internists in both the short and longterm [34]. In the current century, the virtual world provides online CME to keep graduate clinicians' knowledge and practice up-to-date, which consequently leads to better patient care processes and outcomes [24]. The present study assessed the impact of online CME on the knowledge of physicians in the management of type 2 diabetes in Iran. The results showed that approximately 57% of physicians were employed in large cities and mostly in public healthcare services. Fifty-one percent of them had previously taken part in a traditional CME activity. The intervention was effective in increasing the knowledge of the participants regarding the diagnosis of diabetes and glycemic control. Most of the participants gave correct answers to the questions targeting the goal of HbA1c (80%) and HbA1c testing frequency (90%) after the posttest. Currently, good glycemic control is a cornerstone of diabetes care and HbA1c (a valuable test for clinical decision making) is the key biomarker of long-term glycemic control [35]. The positive impact of the intervention on the participants' knowledge of good glycemic control and HbA1c testing may improve the quality of diabetes care. Crenshaw et al. (2010) found the impact of web-based interventions and CME programs was related to the level of participation; because doctors of the patients with the worst A1c control were too busy to participate in these educating progams [26]. Gallardo-Rincon et al. (2017) in the CASAUD Model described the linkages between health care, diabetes patient health knowledge, diabetes self-management activities, and some diabetes biomarkers. This study concluded online CME is a feasible strategy for improvement in quality of health care [36].
The impact of the online CME program on physicians' knowledge in the management of diabetes through lifestyle modification, use of OGLDs, and insulin therapy was evaluated. More than 90% of the participants recommended lifestyle modification from the onset of diabetes. Advice on a healthy diet and physical activity improved after the post-test. There was a significant improvement in the appropriate use of OGLDs and a stepwise approach to insulin therapy recommendations after the intervention. Proper OGLDs therapy and early insulin intensification with patient self-management education are essential for better outcomes and for reducing the risk of long-term complications of diabetes. Physicianrelated barriers may be overcome by providing physicians with education and training. Moreover, online CME programs keep physicians updated about current diabetes guidelines [37]. Similar to our finding, Hicks & Murano (2017) concluded lifestyle-focused online CME programs improved knowledge of physicians [27]. In addition, recent studies emphasized the success of online video-based CME on improving knowledge of primary care physicians related to diabetes management and insulin therapy [38,39].
Numerous systematic reviews and meta-analyses have assessed the effectiveness of CME [40][41][42][43][44] and online CME [20,22] interventions on physicians' knowledge, skills, and professional performance. In a sysnthesis of 39 systematic reviews, Cervero et al. (2015) concluded that CME activity leads to more positive outcomes if it has several characteristics, including being more interactive, using more methods, involving multiple exposures, lasting longer, and being focused on outcomes. However, few studies have examined the effects of online CME on the knowledge and practice of professional health practitioners in the management of type 2 diabetes [45]. Beaser et al. (2013) recommended a new approach for diabetes-focused CME and emphasized performance improvement CME [46]. A recent publication reported that a one-hour online CME course can assist practicing physicians in addressing patient nutrition and lifestyle concerns related to type 2 diabetes [27]. Similar to the current research, this publication reported the positive impact of a single online diabetesfocused CME on physicians' knowledge; however, the sample size in the reported study was low (especially concerning GPs and medical internists) and covered various areas of practice specialties and nutritionfocused CME on Type 2 diabetes [27].
The present study also compared the effect of online CME on GPs and internists. Overall, internists had a better knowledge of diabetes management than GPs. Subgroup analyses revealed that the intervention increased the rate of correct responses among GPs in various domains of knowledge. Hence, the differences no longer remained significant after the intervention. In other words, taking part in the program was more effective for the GPs as the frontline physicians to tackle diabetes management. A cross-sectional study revealed a lack of knowledge, attitude, and practice among primary healthcare physicians, especially family physicians working in rural areas, regarding the management of diabetes [47]. Katulanda et al. [9] suggested the knowledge and practices related to diabetes of GPs in developing countries needs to be updated regarding diagnostic approach, monitoring glycemic control, and setting appropriate glycemic targets by sustained medical education and training programs. A previous survey indicated that the knowledge and practice of Iranian GPs in the management of type 2 diabetes were insufficient, and traditional CME programs were not effective in changing their clinical practice [31]. Niroomand et al. [48] evaluated the knowledge, attitude, and practice of Iranian internists regarding diabetes mellitus and concluded that age and time since graduation were inversely correlated with internists' knowledge and practice, except for physicians who worked in teaching hospitals. Lim et al. (2020) reported significant improvements in diabetes-related knowledge, skills, and clinical practice among general physicians and nurses through a six-month training program called the Steno REACH Certificate Course in Clinical Diabetes Care (SRCC) [49].
In the current study, the impact of online CME on physicians' knowledge regarding diabetes management was examined. One of the strengths of the study is that physicians from small cities and villages had the opportunity to participate. Moreover, this study showed the effectiveness of online CME intervention on GPs' knowledge in diabetes management. However, the short time period for post-intervention assessment is a limitation of this study. Future research should investigate the impact of online programs in clinical practice and patients' outcomes over a long-term period.

Conclusions
In summary, this study demonstrated that knowledge of diabetes among Iranian primary healthcare professionals has significant shortcomings. It further demonstrated the effectiveness of an online CME program in the knowledge of general practitioners regarding the management of type 2 diabetes. In addition, up-to-date online CME is a good option for expanding the number of certified primary healthcare professionals in diabetes management.