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Table 2 Questions, standard answers, and Angoff score

From: Chinese ICU physicians’ knowledge of antibiotic pharmacokinetics/pharmacodynamics (PK/PD): a cross-sectional survey

Question Answer Correct answer Angoff score Pass rate
1. Which of the following antibiotics is liposoluble? A. Ceftazidime
B. Daptomycin
C. Amikacin
D. Moxifloxacin
D 0.645 46.37%
2. Which of the following antibiotics is water soluble? A. Levofloxacin
B. Imipenem
C. Tegacyclin
D. Lincomycin
B 0.675 72.58%
3. Which of the following antibiotics is a concentration-dependent antibiotic? A. Meropenem
B. Tegacyclin
C. Nanofloxacin
D. Ceftriaxone
C 0.670 79.60%
4. Which of the following antibiotics is time dependent? A. Netilmicin
B. Gatifloxacin
C. Aztreonam
D. Polymyxin
C 0.655 80.16%
5. Which of the following evaluation indicators is correct? A. Ceftriaxone% T >mic
B. Isopalmicin% T >mic
C. MeropenemCmax/Mic
D. TegacyclinCmax/Mic
A 0.585 69.44%
6. Which of the following is not a high plasma protein binding drug (PB> 70%)? A. Tegacyclin
B. Daptomycin
C. Teicoplanin
D. Fosfomycin
D 0.515 66.13%
7. Which of the following antibiotics does not need to be adjusted for hypoproteinaemia? A. Cefoperazonesulbactam
B. Doxycycline
C. Teicoplanin
D. Linezolid
D 0.590 48.47%
8. Which of the following antibiotics is mainly excreted through the kidney? A. Minocycline
B. Azithromycin
C. Lincomycin
D. Vancomycin
D 0.710 91.37%
9. Which of the following antibiotics is mainly excreted through the liver? A. Imipenem/cilastatin
B. Teicoplanin
C. Clarithromycin
D. Cefoperazone
D 0.600 44.35%
10. How should one adjust time-dependent antibiotics in critically ill patients? A. Reduce dosage, increase frequency, and prolong infusion time
B. Increase dosage, reduce frequency, and prolong infusion time
C. Multiple daily doses, increase administration frequency, and prolong infusion time
D. Single daily dose, increase dose, and extend infusion time
C 0.655 69.84%
11. Which of the following conditions will not lead to an increase in the apparent distribution volume (Vd) of antibiotics? A. Hypoproteinemia
B. Fluid resuscitation
C. Severe infection
D. Short bowel syndrome
D 0.595 78.47%
12. Which of the following statements is correct? A. The main evaluation index of time-dependent antibiotic is% T >mic
B. Auc0-24/MIC is the main evaluation index for concentration dependent antibiotic
C. Cmax/MIC is the main evaluation index for time-dependent and PAE long antibiotics
D. Time-dependent antibiotics with Cmax/MIC = 10-12
A 0.650 69.35%
13. What is the approximate half-life of an antibiotic with Vd of 200 L and CL of 10 L/h? A. 12 h B. 14 h C. 16 h D. 18 h B 0.485 35.65%
14. Which of the following antibiotics does not require dose adjustment during CRRT? A. Water-soluble antibiotics
B. Antibiotics with low plasma protein binding rate
C. Antibiotics with high Vd
D. Antibiotics with low molecular weight
C 0.550 75.56%
15. How should one adjust antibiotics with high Pb and low Vd during plasma exchange? A. Extend infusion time
B. Increase dosage
C. Prolong infusion time and increase dosage
D. Prolong interval of plasma exchange
D 0.500 38.31%