Table 2 Questions, standard answers, and Angoff score
Question | Answer | Correct answer | Angoff score | Pass rate |
|---|---|---|---|---|
1. Which of the following antibiotics is liposoluble? | A. Ceftazidime B. Daptomycin C. Amikacin D. Moxifloxacin | D | 0.645 | 46.37% |
2. Which of the following antibiotics is water soluble? | A. Levofloxacin B. Imipenem C. Tegacyclin D. Lincomycin | B | 0.675 | 72.58% |
3. Which of the following antibiotics is a concentration-dependent antibiotic? | A. Meropenem B. Tegacyclin C. Nanofloxacin D. Ceftriaxone | C | 0.670 | 79.60% |
4. Which of the following antibiotics is time dependent? | A. Netilmicin B. Gatifloxacin C. Aztreonam D. Polymyxin | C | 0.655 | 80.16% |
5. Which of the following evaluation indicators is correct? | A. Ceftriaxone% T >mic B. Isopalmicin% T >mic C. MeropenemCmax/Mic D. TegacyclinCmax/Mic | A | 0.585 | 69.44% |
6. Which of the following is not a high plasma protein binding drug (PB> 70%)? | A. Tegacyclin B. Daptomycin C. Teicoplanin D. Fosfomycin | D | 0.515 | 66.13% |
7. Which of the following antibiotics does not need to be adjusted for hypoproteinaemia? | A. Cefoperazonesulbactam B. Doxycycline C. Teicoplanin D. Linezolid | D | 0.590 | 48.47% |
8. Which of the following antibiotics is mainly excreted through the kidney? | A. Minocycline B. Azithromycin C. Lincomycin D. Vancomycin | D | 0.710 | 91.37% |
9. Which of the following antibiotics is mainly excreted through the liver? | A. Imipenem/cilastatin B. Teicoplanin C. Clarithromycin D. Cefoperazone | D | 0.600 | 44.35% |
10. How should one adjust time-dependent antibiotics in critically ill patients? | A. Reduce dosage, increase frequency, and prolong infusion time B. Increase dosage, reduce frequency, and prolong infusion time C. Multiple daily doses, increase administration frequency, and prolong infusion time D. Single daily dose, increase dose, and extend infusion time | C | 0.655 | 69.84% |
11. Which of the following conditions will not lead to an increase in the apparent distribution volume (Vd) of antibiotics? | A. Hypoproteinemia B. Fluid resuscitation C. Severe infection D. Short bowel syndrome | D | 0.595 | 78.47% |
12. Which of the following statements is correct? | A. The main evaluation index of time-dependent antibiotic is% T >mic B. Auc0-24/MIC is the main evaluation index for concentration dependent antibiotic C. Cmax/MIC is the main evaluation index for time-dependent and PAE long antibiotics D. Time-dependent antibiotics with Cmax/MIC = 10-12 | A | 0.650 | 69.35% |
13. What is the approximate half-life of an antibiotic with Vd of 200 L and CL of 10 L/h? | A. 12 h B. 14 h C. 16 h D. 18 h | B | 0.485 | 35.65% |
14. Which of the following antibiotics does not require dose adjustment during CRRT? | A. Water-soluble antibiotics B. Antibiotics with low plasma protein binding rate C. Antibiotics with high Vd D. Antibiotics with low molecular weight | C | 0.550 | 75.56% |
15. How should one adjust antibiotics with high Pb and low Vd during plasma exchange? | A. Extend infusion time B. Increase dosage C. Prolong infusion time and increase dosage D. Prolong interval of plasma exchange | D | 0.500 | 38.31% |