Table 3 Stress and anxiety assessment in global TCG2 (Traditional Group 2) and FCG2 (Flipped Classroom Group 2. IQR: Interquartile range. SISCO: Inventory of Academic Stress. Data are expressed in medians and interquartile ranges. * denotes significant differences in comparison to the first measurement in the same group (p < 0.01). A: Intensity of academic stress. B: Environment stressful stimulus. C: Physical reactions. D: Psychological reactions. E: Behavioral reactions. F: Coping strategies

66 (44–86)

72 (50–87)

52 (44–70)

97 (59–125)

64 (39–99)

77 (57–123)

41 (38–48)

43 (38–50)

48 (42–57)

40 (36–48)

47 (43–54)

50 (44–56)

SISCO

A

4 (3–4.2)

4 (3–4)

4 (4–5)

4 (3–4)

4 (3–4)

4 (3–5)

B

2.6 (2.2–3.1)

3.2 (3.1–4)*

3.2 (3–4)

3.1 (2.7–3.3)

3.7 (3.3–4.1)*

3.6 (3.3–4.1)

C

2.3 (1.8–2.8)

3.1 (3–3.3)*

3.5 (2.8–4)

3.1 (2.5–3.3)

3.3 (3–3.8)

3.3 (3–3.8)

D

2.2 (2–2.8)

3.4 (2.8–3.8)*

3.8 (3.2–4.2)

3.2 (2.8–3.4)

3.4 (3–3.8)

3.6 (3.2–4.2)

E

1.7 (1–2)

2.7 (2.5–3.2)*

2.7 (2.2–3.2)

2.7 (2.5–3)

3.5 (2.9–3.7)*

3 (2.7–3.7)

F

2.3 (1.8–2.8)

3.1 (3.1–3.5)*

3.3 (3–3.6)

2.8 (2.5–3.3)

3 (2.8–3.5)

3.1 (2.6–3.6)