Table 2 Stress and anxiety assessment in TG1 (Traditional Group 1) and FCG1 (Flipped Classroom Group 1). IQR: Interquartile range. SISCO: Inventory of Academic Stress. Data are expressed in medians and interquartile ranges. * denotes significant differences in comparison to the first measurement in the same group (p < 0.01). A: Intensity of academic stress. B: Environment stressful stimulus. C: Physical reactions. D: Psychological reactions. E: Behavioral reactions. F: Coping strategies

31 (17–50)

57 (41–89)*

41 (24–80)

29 (21–80)

48 (26–85)*

48 (24–104)

40 (30–44)

37 (30–42)

37 (32–44)

37 (33–44)

43 (32–50)

43 (32–48)

SISCO

A

4 (3–4.25)

4 (3–4)

4 (4–5)

4 (3–4)

4 (3–4)

4 (3–5)

B

2.7 (2.4–3.1)

2.7 (1.9–3.3)

2.6 (1.9–3.2)

3.2 (2.5–3.6)

3.5 (2.7–4.3)

3.5 (2.7–3.7)

C

2.6 (1.5–2.9)

2.3 (1.7–3.2)

2.3 (1.8–3)

2.7 (1.8–3.3)

3.2 (1.8–3.6)

3.2 (2.3–3.5)

D

2.7 (2.1–3.6)

2.7 (2.1–3.1)

2.8 (2.5–3.1)

3.2 (2.4–3)

3 (2.6–4.4)

3 (2.6–3.6)

E

2.7 (2.2–3.0)

2.6 (2.0–3.1)

3 (2.4–3.3)

2.7 (2.3–3)

2.7 (2.5–3.5)

3 (2.3–3.3)

F

2.8 (2.6–3.7)

3.3 (2.6–3.7)

3 (2.5–3.8)

2.8 (2.5–3.1)

2.8 (2.3–3.6)

2.7 (2.6–3.3)