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Table 2 Risk of bias appraisal of included systematic reviews

From: Changing prescribing behaviours with educational outreach: an overview of evidence and practice

Criterion (AMSTAR 2)

Alagoz et al. (2018) [20]

Baker et al. (2015) [21]

Chauhan et al. (2017) [22]

Chhina et al. (2013) [23]

Clyne et al. (2016) [2]

Forsetlund et al. (2011) [24]

Green et al. (2012) [25]

Johnson and May (2015) [26]

Kamarudin et al. (2013) [27]

Loganathan et al. (2011) [28]

O’Brien et al. (2008) [6]

Ostini et al. (2009) [29]

Smith et al., (2010) [19]

Thompson Coon et al. (2014) [30]

1. Did the research questions and inclusion criteria for the review include the components of PICO?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

–

Yes

2. Did the report of the review contain an explicit statement that the review methods were established prior to the conduct of the review and did the report justify any significant deviations from the protocol?

No

No

Yes

No

No

No

Yes

Yes

No

No

No

No

–

Yes

3. Did the review authors explain their selection of study designs for inclusion in the review?

No

No

No

No

No

No

No

No

No

No

No

No

–

No

4. Did the review authors use a comprehensive literature search strategy?

Partial yes

Yes

Partial yes

Partial yes

Partial yes

Partial Yes

Partial yes

Partial yes

Partial yes

Partial yes

Partial yes

Partial yes

–

Partial yes

5. Did the review authors perform the study selection in duplicate?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

–

Yes

6. Did the review authors perform data extraction in duplicate?

No

Yes

Yes

Yes

No

No

No

No

Yes

No

Yes

Yes

–

No

7. Did the review authors provide a list of excluded studies and justify the exclusion?

Partial yes

Yes

No

No

No

Partial Yes

No

No

No

No

Yes

No

–

No

8. Did the review authors describe the included studies in adequate detail?

Partial yes

Yes

Partial yes

Partial yes

Yes

Partial Yes

Partial yes

Partial yes

No

Partial yes

Partial yes

No

–

Partial yes

9. Did the review authors use a satisfactory technique for assessing the risk of bias in individual studies that were included in the review?

Yes

Yes

Yes

Partial yes

Yes

Partial Yes

Yes

Yes

No

Partial yes

Partial yes

Unclear

–

No

10. Did the review authors report on the sources of funding for the studies included in the review?

No

No

Yes

No

Yes

No

No

No

Yes

No

No

No

–

No

11. If meta-analysis was performed, did the review authors use appropriate methods for statistical combination of results?

N/A

Yes

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Yes

N/A

–

N/A

12. If meta-analysis was performed, did the review authors assess the potential impact of risk of bias in individual studies on the results of the meta-analyses or other evidence synthesis?

N/A

Yes

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

Yes

N/A

–

N/A

13. Did the authors account for risk of bias in individual studies when interpreting/discussing the results of the review?

Yes

Yes

Yes

No

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

–

Yes

14. Did the review authors provide a satisfactory explanation for and discussion of heterogeneity observed in the results of the review?

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

–

Yes

15. If they performed quantitative synthesis, did the review authors carry out an adequate investigation of publication bias (small study bias and discuss its likely impact on the results of the review)?

N/A

No

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

No

N/A

–

N/A

16. Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review?

Yes

Yes

Yes

Yes

No

Yes

No

Yes

Yes

No

Yes

No

–

Yes

TOTAL yes / applicable items (%)

9/13 (69%)

12/16 (75%)

11/12 (92%)

8/13 (62%)

8/13 (62%)

9/13 (69%)

8/12 (66%)

9/12 (75%)

8/13 (62%)

7/13 (54%)

12/16 (75%)

5/13 (38%)

–

8/13 (62%)