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Fig. 1 | BMC Medical Education

Fig. 1

From: The understanding of core pharmacological concepts among health care students in their final semester

Fig. 1

The two patient cases that were presented to the interviewees for discussion. Case A The patient is prescribed omeprazole (a proton pump inhibitor) in combination with the prodrug clopidogrel, an inhibitor of platelet aggregation (P2Y12 purinoceptor antagonist). Since clopidogrel is activated by an enzyme (CYP2C19) that is inhibited by omeprazole possible effects of an interaction may appear, which should be considered by the interviewed. Case B The patient is prescribed acetylsalicylic acid (at a low dose) because of cardiovascular events. The patient wants it to be replaced by another non-steroid, anti-inflammatory drug (NSAID) or paracetamol (acetaminophen). The discussion of this case requires the understanding of the mechanism of action of NSAIDs (reversible and irreversible cyclooxygenase binding) and its relevance for the dosage

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