Table 2 Major outcome and learning objectives for the intermittent intravenous infusion session

 1.1 Estimate major kinetic parameters (elimination rate constant or half life, volume of distribution, and clearance) from two or more plasma concentration-time data collected after intermittent intravenous infusion of drugs during the first dose or at steady state.

2.

Learning objectives:

 2.1 Define the applications of intermittent intravenous infusion method.

 2.2 Recognize the differences between the maximum and peak and between the minimum and trough concentrations.

 2.3 Estimate the elimination rate constant and half life from the peak and trough concentrations after the first dose.

 2.4 Estimate elimination rate constant and half life from a trough concentration collected at the end of one dosage interval and a peak concentration collected subsequently after the infusion of the next dose at steady state.

 2.5 Estimate the maximum and minimum concentrations from the peak or trough concentrations and elimination rate constant for the first dose or at steady state.

 2.6 Estimate volume of distribution after the first dose or at steady state.

 2.7 Estimate clearance after the first dose or at steady state.